منابع مشابه
RNAa Is Conserved in Mammalian Cells
BACKGROUND RNA activation (RNAa) is a newly discovered mechanism of gene activation triggered by small double-stranded RNAs termed 'small activating RNAs' (saRNAs). Thus far, RNAa has only been demonstrated in human cells and is unclear whether it is conserved in other mammals. METHODOLOGY/PRINCIPAL FINDINGS In the present study, we evaluated RNAa in cells derived from four mammalian species ...
متن کاملDefining features and exploring chemical modifications to manipulate RNAa activity.
RNA interference (RNAi) is an evolutionary conserved mechanism by which small double-stranded RNA (dsRNA)--termed small interfering RNA (siRNA)--inhibit translation or degrade complementary mRNA sequences. Identifying features and enzymatic components of the RNAi pathway have led to the design of highly-effective siRNA molecules for laboratory and therapeutic application. RNA activation (RNAa) ...
متن کاملAB74. MicroRNAs fuels cancer growth through the RNAa mechanism
MicroRNAs (miRNAs) are master regulators of gene expression and have been known to be involved in cancer by acting either as tumor suppressors or oncomiRs. It is widely accepted that the miRNAs carry out their functions in the cytoplasm via targeting the 3’ UTR region of mRNAs leading to downregulation of gene expression. However, whether and how miRNAs function in the nucleus remains largely u...
متن کاملRNAi and RNAa - The Yin and Yang of RNAome
RNA interference (RNAi) is a powerful technology with huge applications for functional genomics, target identification in drug discovery and elucidation of molecular signaling pathways. Current RNAi studies have demonstrated the clinical potential of small interfering RNAs (siRNAs) in metabolic diseases, cancer, AIDS, malaria, neurodegenerative disorders, dental diseases and other illnesses. In...
متن کاملRNAa-mediated overexpression of WT1 induces apoptosis in HepG2 cells
AIM Recent studies have reported that double-stranded RNA (dsRNA) can activate gene expression by targeting promoter sequence in a process termed RNA activation. The present study was conducted to evaluate the potential of WT1 induction by small activating RNA targeting the WT1 promoter (dsWT1) in the treatment of hepatocellular carcinoma. METHODS The human hepatocellular carcinoma cell line ...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2008
ISSN: 1945-3477
DOI: 10.1038/scibx.2008.668